Abstract |
A pulse sequence with magnetization transfer as the main contrast mechanism (MT-FLASH) was developed for improved imaging of breast lesions that requires neither fat suppression nor postprocessing. After optimization of the sequence in phantom and volunteer studies, a clinical pilot study with 14 patients was performed. In carcinomas the relative signal increase after Gd-DTPA administration was on average 34% in MT-FLASH images compared with 169% in conventional T1-weighted (T1W) three-dimensional FLASH images. In MT-FLASH images, all lesions demonstrated a signal intensity higher than that of fat; in T1W images, all lesions have a lower signal intensity. The average postcontrast carcinoma-to-fat contrast-to-noise ratios were +11.6 and -14.2, respectively. The conspicuity of 12 of 13 carcinomas was improved in postcontrast MT-FLASH imaging enables excellent visualization of Gd-DTPA-enhancing breast lesions.
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Authors | W G Schreiber, G Brix, M V Knopp, T Hess, W J Lorenz |
Journal | Magnetic resonance in medicine
(Magn Reson Med)
Vol. 35
Issue 6
Pg. 861-9
(Jun 1996)
ISSN: 0740-3194 [Print] United States |
PMID | 8744014
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Contrast Media
- Organometallic Compounds
- Pentetic Acid
- Gadolinium DTPA
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Topics |
- Adult
- Aged
- Breast
(anatomy & histology, pathology)
- Breast Neoplasms
(diagnosis)
- Carcinoma, Ductal, Breast
(diagnosis)
- Contrast Media
- Female
- Fibrocystic Breast Disease
(diagnosis)
- Gadolinium DTPA
- Humans
- Magnetic Resonance Imaging
(methods)
- Middle Aged
- Organometallic Compounds
- Pentetic Acid
(analogs & derivatives)
- Phantoms, Imaging
- Pilot Projects
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