The effect of 2-chloroadenosine on the ATP level Na,K ATPase activity in experimental brain ischemia of gerbil.

Abstract

T1. The effect of 2-chloroadenosine, an adenosine analogue, on brain ATP level and Na,K ATPase activity in ischemia and reperfusion was studied. 2. Na,K ATPase activity decreased in both ischemia and reperfusion. Although the ATP level decreased in ischemia, it increased with reperfusion (P < 0.05). 3. It is concluded that 2-chloroadenosine treatment influenced ATP production and Na,K ATPase activity in ischemia and reperfusion (P < 0.05).

• Authors: N Türközkan, S Aykol, A Bilgihan, O Yavuz, B Cayci, F Doğulu
• Journal: General pharmacology (Gen Pharmacol) Vol. 27 Issue 1 Pg. 165-6 (Jan 1996) ISSN: 0306-3623 [Print] England
• PMID: 8742515 (Publication Type: Journal Article)

Chemical References

• Purinergic P1 Receptor Antagonists
• 2-Chloroadenosine
• Adenosine Triphosphate
• Sodium-Potassium-Exchanging ATPase

Topics

• 2-Chloroadenosine (pharmacology)
• Adenosine Triphosphate (metabolism)
• Animals
• Brain (enzymology)
• Brain Ischemia (drug therapy, metabolism)
• Female
• Gerbillinae
• Male
• Purinergic P1 Receptor Antagonists
• Reperfusion
• Sodium-Potassium-Exchanging ATPase (metabolism)