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[Ceramide: a lipid mediator of apoptotic signal transduction].

Abstract
Ceramide, the backbone of sphingolipids, is now recognized as an intracellular signal mediator of various cellular responses including cell differentiation and apoptosis. Tumor necrosis factor-alpha, anti-Fas antibody, anticancer drugs, radiation or heat shock induce apoptosis through generation of ceramide by activation of sphingomyelinase or ceramide synthase. The mechanism by which ceramide mediates apoptosis is unclear. We have found that ceramide induces the transcription of c-jun gene and increases the DNA binding activity of transcription factor AP-1 in human myelogenous leukemia HL-60 cells, and that activation of c-jun/AP-1 by ceramide(presumably through activation of Jun N-terminal kinase/stress-activated protein kinase) may be involved in the signaling pathway leading to apoptosis.
AuthorsH Sawai, T Okazaki, N Domae
JournalNihon rinsho. Japanese journal of clinical medicine (Nihon Rinsho) Vol. 54 Issue 7 Pg. 1803-8 (Jul 1996) ISSN: 0047-1852 [Print] Japan
PMID8741670 (Publication Type: Journal Article, Review)
Chemical References
  • Ceramides
  • Tumor Necrosis Factor-alpha
  • fas Receptor
  • Sphingomyelin Phosphodiesterase
Topics
  • Apoptosis
  • Ceramides (physiology)
  • Genes, jun
  • Humans
  • Signal Transduction
  • Sphingomyelin Phosphodiesterase (metabolism)
  • Transcription, Genetic
  • Tumor Necrosis Factor-alpha
  • fas Receptor

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