The effect of non-activated prothrombin complex concentrate (Proplex ST) on intraperitoneal hematoma in a hemophilia A patient with a factor VIII inhibitor.

Abstract

A 28-year-old severe hemophiliac with a factor VIII inhibitor was admitted to our hospital with a massive and serious intraperitoneal hematoma. He was a high-responder patient showing maximal serum inhibitor levels as high as 255 Bethesda Units/ml (BU/ml). He was successfully treated with "bypass therapy" using a prothrombin complex concentrate (PCC).

• Authors: H Kagawa, M Yasuzawa, Y Ozaki, Y Yamamoto, T Katsurada, S Nomura, S Okubo, S Fukuhara
• Journal: Internal medicine (Tokyo, Japan) (Intern Med) Vol. 35 Issue 4 Pg. 319-22 (Apr 1996) ISSN: 0918-2918 [Print] Japan
• PMID: 8739790 (Publication Type: Case Reports, Journal Article)

Chemical References

• Blood Coagulation Factors
• prothrombin complex concentrates
• Factor VIII

Topics

• Adult
• Blood Coagulation Factors (therapeutic use)
• Factor VIII (antagonists & inhibitors)
• Hematoma (complications, diagnosis, drug therapy)
• Hemophilia A (blood, complications, drug therapy)
• Humans
• Male
• Peritoneal Diseases (complications, diagnosis, drug therapy)