Abstract |
Oxerutins (O-(beta-hydroxyethyl)rutosides, HR, Venoruton) and horse chestnut extract ( HCE) are active principles of first priority for the pharmacological treatment of chronic venous insufficiency (CVI). The efficacies of both compounds were shown in numerous, double-blind, randomized, placebo controlled clinical trials. Besides the direct comparison of the two compounds the aim of the study was to investigate the initial dose/maintenance dose concept for HR. 137 female, postmenopausal patients with CVI II finished the study according to protocol. Following one week placebo run-in the patients were treated either with 1000 mg/d HR, 600 mg/d HCE or 1000 mg/d for 4 weeks and than with 500 mg/d HR within the initial dose/maintainance dose concept for 12 weeks and observed for further 6 weeks. A main confirmative criterion was the volume reduction of the leg. Subjective criteria were descriptively evaluated. HR (1000 mg/d) was proven to be equivalent or better, reducing the leg volume (AUB0-18) by -5273 +/- 11418 ml.d compared to -3187 +/- 10842 ml.d under HR (1000 mg/d and 500 mg/d), and -3004 +/- 7429 ml.d under HCE-treatment. Both compounds exhibit a substantial carry-over effect. The maintenance posology of HR is able to stabilize the therapeutic obtained under initial dose conditions.
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Authors | D Rehn, M Unkauf, P Klein, V Jost, P W Lücker |
Journal | Arzneimittel-Forschung
(Arzneimittelforschung)
Vol. 46
Issue 5
Pg. 483-7
(May 1996)
ISSN: 0004-4172 [Print] Germany |
PMID | 8737631
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Multicenter Study, Randomized Controlled Trial)
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Chemical References |
- Hydroxyethylrutoside
- Plant Extracts
- Vasoconstrictor Agents
- troxerutin
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Topics |
- Aged
- Bandages
- Chronic Disease
- Combined Modality Therapy
- Double-Blind Method
- Female
- Humans
- Hydroxyethylrutoside
(adverse effects, analogs & derivatives, therapeutic use)
- Leg
(anatomy & histology)
- Microcirculation
- Middle Aged
- Plant Extracts
(adverse effects, therapeutic use)
- Plants, Medicinal
(chemistry)
- Vasoconstrictor Agents
(adverse effects, therapeutic use)
- Venous Insufficiency
(drug therapy, pathology, therapy)
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