[Plasma kallikrein clearance by the liver in experimental cirrhosis].

Abstract

AIM:

To study the hepatic clearance of a glycoprotein (rat plasma kallikrein) by the liver of rats with experimental decompensated cirrhosis.

MATERIAL AND METHODS:

Cirrhosis was induced by intragastrically administration of carbon tetrachloride 520 mg/kg/week, during 16-19 weeks. After this period, each liver was isolated, exsanguinated and perfused at 37 degrees C with 10nM rat plasma kallikrein (RPK).

RESULTS:

58% of the animals died during the treatment and the remaining developed prostration, ascites, jaundice and bleeding; at the end of the treatment period serum aminotransferases were not altered and serum albumin decreased. The liver histology showed cirrhosis. RPK clearance rate of the cirrhosis group (5.4 +/- 0.9 pmol/g liver/10 min) was significantly lower (p < 0.05) than that of the control group (13.5 +/- 2.7 pmol/g liver/10 min).

CONCLUSION:

The development of cirrhosis is associated with a decreased hepatic clearance of a glycoprotein which endocytosis is mediated by a receptor.

• Authors: C F de Toledo, M R Loureiro-Silva, H M Molina, V P Lanzoni, M Kouyoumdjian, D R Borges
• Journal: Revista da Associacao Medica Brasileira (1992) (Rev Assoc Med Bras (1992)) 1995 Nov-Dec Vol. 41 Issue 6 Pg. 367-72 ISSN: 0104-4230 [Print] Brazil
• Vernacular Title: Depuração hepática da calicreína plasmática na cirrose experimental.
• PMID: 8733244 (Publication Type: English Abstract, Journal Article)

Chemical References

• Carbon Tetrachloride
• Kallikreins

Topics

• Age Factors
• Analysis of Variance
• Animals
• Body Weight (drug effects)
• Carbon Tetrachloride (administration & dosage)
• Kallikreins (metabolism)
• Liver (metabolism)
• Liver Cirrhosis, Experimental (physiopathology)
• Metabolic Clearance Rate
• Organ Size (drug effects)
• Perfusion
• Prognosis
• Rats
• Rats, Wistar