Abstract |
Endogenous nerve growth factor ( NGF) levels were studied in patients with nerve trauma, diabetes mellitus and leprosy, the most common causes of human peripheral neuropathy. In diabetics, there was an early length-dependent dysfunction of small-diameter sensory fibres, with depletion of skin NGF and the sensory neuropeptide substance P. The NGF depletion correlated significantly with decreased skin axon-reflex vasodilatation, which is mediated by small sensory fibres at least partly via substance P release. Immunostaining showed depletion of NGF in keratinocytes in diabetic skin. In injured nerves, NGF levels were reduced when compared to intact nerve, except acutely distal to injury; NGF-immunostaining was seen in Schwann cells in distal segments, including neuromas. NGF levels were decreased in leprosy-affected skin and nerve. The role of neurotrophins in the rational treatment of human neuropathies is discussed e.g. loss of nociception and axon-reflex vasodilatation contribute to skin ulceration, a major and serious complication, for which NGF may provide prophylaxis.
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Authors | P Anand |
Journal | Philosophical transactions of the Royal Society of London. Series B, Biological sciences
(Philos Trans R Soc Lond B Biol Sci)
Vol. 351
Issue 1338
Pg. 449-54
(Mar 29 1996)
ISSN: 0962-8436 [Print] England |
PMID | 8730784
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
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Topics |
- Animals
- Diabetic Neuropathies
(etiology)
- Humans
- Hyperalgesia
(chemically induced)
- Leprosy
(complications)
- Nerve Growth Factors
(physiology, toxicity)
- Nociceptors
(physiology)
- Peripheral Nerve Injuries
- Peripheral Nervous System Diseases
(etiology)
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