Association of diet and colorectal adenomatous polyps: dietary fiber, calcium, and total fat.

Abstract

We conducted a case-control study to investigate the relation between dietary fiber, calcium, and total fat and the risk of colorectal adenomatous polyps. We used a food frequency questionnaire to assess the usual diet for 157 cases and 480 controls. In multivariate analyses, dietary fiber was inversely associated with risk of adenomatous polyps. The odds ratio (OR) for individuals in the highest vs the lowest quartile was 0.5 [95% confidence interval (CI) = 0.3-0.9]. We found an inverse association between dietary calcium and risk of adenomatous polyps, but the protective effect was present only for individuals in the fourth vs the first quartile (OR = 0.7; 95% CI = 0.3-1.3). Intake of total fat was positively associated with risk of adenomatous polyps, but we saw no consistent trend. Calcium intake appeared to modify the effect of total fat intake on the risk of adenomatous polyps.

• Authors: M E Martínez, R S McPherson, J F Annegers, B Levin
• Journal: Epidemiology (Cambridge, Mass.) (Epidemiology) Vol. 7 Issue 3 Pg. 264-8 (May 1996) ISSN: 1044-3983 [Print] United States
• PMID: 8728439 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Calcium, Dietary
• Dietary Fats
• Dietary Fiber

Topics

• Adenomatous Polyps (epidemiology, prevention & control)
• Adult
• Aged
• Calcium, Dietary (administration & dosage)
• Case-Control Studies
• Colorectal Neoplasms (epidemiology, prevention & control)
• Cross-Sectional Studies
• Dietary Fats (administration & dosage)
• Dietary Fiber (administration & dosage)
• Feeding Behavior
• Female
• Humans
• Incidence
• Male
• Middle Aged
• Multivariate Analysis
• Nutritional Requirements
• Odds Ratio
• Risk
• Texas (epidemiology)