[Hypoplastic mixed lineage leukemia successfully treated with low-dose cytosine arabinoside].

Abstract

A 54-year-old male was admitted because of dyspnea on exercise. His peripheral blood revealed pancytopenia with severely hypoplastic bone marrow. Bone marrow aspiration showed a marked hypocellular marrow with 62.4% of blast cells. Cytochemical studies showed that peroxidase activity, alpha-nephtyl buthylate esterase activity and PAS reaction were negative, and that only ASD-chroloacetate esterase activity was positive. Surface marker analysis of blast cells showed positive result for CD5, 7, 33 and 34 antigens. The T-cell receptor beta gene was rearranged, but the immunoglobulin H chain gene showed a germ line configuration. Terminal Deoxynucleotydyl Transferase (TdT) was positive, but cellular surface and cytoplasmic immunoglobulin were not recognized. A diagnosis of hypoplastic mixed lineage leukemia was made and treated with low dose cytosine arabinoside, he resulted in complete remission. The relation between hypoplastic leukemia, AML-M0 and mixed lineage leukemia was also discussed.

• Authors: S Sasaki, S Ueda, Y Asakura, E Yamazaki, K Kato, J Taguchi, H Harano, H Kanamori, K Ogawa, M Otsuka, M Matuszaki, H Mohri, T Okubo
• Journal: [Rinsho ketsueki] The Japanese journal of clinical hematology (Rinsho Ketsueki) Vol. 37 Issue 3 Pg. 233-8 (Mar 1996) ISSN: 0485-1439 [Print] Japan
• PMID: 8727348 (Publication Type: Case Reports, English Abstract, Journal Article)

Chemical References

• Antimetabolites, Antineoplastic
• Cytarabine

Topics

• Antimetabolites, Antineoplastic (administration & dosage)
• Cytarabine (administration & dosage)
• Humans
• Leukemia, Biphenotypic, Acute (blood, drug therapy, pathology)
• Male
• Middle Aged