Abstract | BACKGROUND: CASE: In a case of a long-term survivor of high-risk advanced-stage ovarian serous tumor of low malignant potential, suboptimal primary cytoreductive surgery was performed; at that time it was found that the tumor had directly invaded the outer uterine wall and rectosigmoid colon serosa and had metastasized to the pelvic lymph nodes. Postoperative adjunctive hormonal treatment with leuprolide acetate was administered and resulted in a complete clinical and serologic response. The patient remained disease free 68 months after the initial diagnosis. Her only symptoms were minimal hot flashes and vaginal dryness. CONCLUSION:
Leuprolide acetate may be active in the treatment of ovarian tumors of low malignant potential. It should be considered frontline systemic therapy for this disease.
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Authors | D Tresukosol, A P Kudelka, C L Edwards, E G Silva, M Kanojia, J J Kavanagh |
Journal | The Journal of reproductive medicine
(J Reprod Med)
Vol. 41
Issue 5
Pg. 363-6
(May 1996)
ISSN: 0024-7758 [Print] United States |
PMID | 8725765
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- Antineoplastic Agents, Hormonal
- Leuprolide
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Topics |
- Adult
- Antineoplastic Agents, Hormonal
(adverse effects, therapeutic use)
- Cystadenoma, Serous
(drug therapy, pathology)
- Female
- Humans
- Leuprolide
(adverse effects, therapeutic use)
- Ovarian Neoplasms
(drug therapy, pathology)
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