Abstract |
The present study was designed to examine the role of endogenous sulphydryls (SHs) in the gastro-protection induced by cisapride (CIS) (10, 25 and 50 mg kg-1 i.p.), a potent benzamide stimulating gastrointestinal motility in mucosal injury induced by 50% v/v ethanol. Results were compared with those of 5-hydroxytryptamine (5-HT) (10mg kg-1). Ethanol mucosal damage was significantly reduced by treatment with CIS and 5-HT. On the contrary, administration of n-ethylmaleimide (NEM) (10 mg kg-1) an SH alkylator, markedly worsened lesion formation and counteracted the protective effect of CIS. Rats pretreated with CIS significantly increased the total sulphydryls as reflected in the non- protein and protein fractions however, 5-HT treatment showed a fall in the non- protein level. The present results suggest that 5-HT-ergic dependent mechanisms have no relation to the gastro-protection afforded by CIS in this experimental model. It is possible that mucosal SHs could be involved.
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Authors | A López, V Motilva, C Alarcón de la Lastra, M J Martín, C La Casa |
Journal | The Journal of pharmacy and pharmacology
(J Pharm Pharmacol)
Vol. 48
Issue 1
Pg. 37-40
(Jan 1996)
ISSN: 0022-3573 [Print] England |
PMID | 8722492
(Publication Type: Journal Article)
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Chemical References |
- Anti-Ulcer Agents
- Piperidines
- Sulfhydryl Compounds
- Sulfhydryl Reagents
- Serotonin
- Ethanol
- Ethylmaleimide
- Cisapride
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Topics |
- Animals
- Anti-Ulcer Agents
(administration & dosage, pharmacology, therapeutic use)
- Cisapride
- Disease Models, Animal
- Ethanol
(toxicity)
- Ethylmaleimide
(administration & dosage, metabolism, toxicity)
- Gastric Mucosa
(chemistry, drug effects, metabolism)
- Injections, Intraperitoneal
- Injections, Subcutaneous
- Male
- Piperidines
(administration & dosage, pharmacology, therapeutic use)
- Rats
- Rats, Wistar
- Serotonin
(administration & dosage, pharmacology, therapeutic use)
- Stomach Ulcer
(chemically induced, drug therapy)
- Sulfhydryl Compounds
(analysis, physiology)
- Sulfhydryl Reagents
(administration & dosage, metabolism, toxicity)
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