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Ineffectiveness of sequential high dose methotrexate and 5-fluorouracil combined with epirubicin (FEMTX regimen) as a salvage therapy in advanced colorectal cancers and other gastrointestinal tumors.

Abstract
The combination of sequential high dose methotrexate and 5-fluorouracil (FU) combined with epirubicin (FEMTX regimen) has shown some clinical efficiency as a first line therapy in advanced gastric cancer. We evaluated the therapeutic activity of this combination in advanced colorectal cancer patients who failed the FU + folinic acid regimen, and in advanced gastrointestinal cancer situation where no standard regimen is available. Twelve patients with measurable metastatic colorectal cancer refractory to first line (n = 6) or second line (n = 6) chemotherapy, as well as 9 patients with advanced gastrointestinal cancer, entered this pragmatic pilot study. Eighty-six per cent and 38% of the patients experienced severe haematological or non-haematological toxicities, respectively. Four patients were not evaluable for response due to their early departure from the scheme due to acute toxic events (n = 3) or toxic death (n = 1). No objective response was observed, but 9 stabilisations and 8 progressive diseases were noted. The FEMTX regimen is not of clinical value as a salvage therapy in colorectal and gastrointestinal cancer, because of its toxicity and its lack of efficacy.
AuthorsA Adenis, N Leriche, J M Pion, L Vanlemmens, J Bonneterre
JournalAnticancer research (Anticancer Res) 1996 Jul-Aug Vol. 16 Issue 4A Pg. 2063-7 ISSN: 0250-7005 [Print] Greece
PMID8712743 (Publication Type: Clinical Trial, Journal Article)
Chemical References
  • Epirubicin
  • Leucovorin
  • Fluorouracil
  • Methotrexate
Topics
  • Adult
  • Aged
  • Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
  • Colorectal Neoplasms (drug therapy)
  • Epirubicin (administration & dosage)
  • Esophageal Neoplasms (drug therapy)
  • Female
  • Fluorouracil (administration & dosage, therapeutic use)
  • Gastrointestinal Neoplasms (drug therapy)
  • Humans
  • Leucovorin (therapeutic use)
  • Male
  • Methotrexate (administration & dosage)
  • Middle Aged
  • Neoplasm Metastasis
  • Neoplasm Staging
  • Palliative Care
  • Pancreatic Neoplasms (drug therapy)
  • Pilot Projects
  • Salvage Therapy
  • Treatment Failure

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