Urinary gonadotropin peptide in patients with cancer of digestive organs.

Abstract

Urinary gonadotropin peptide (UGP) has been measured in gynecological and urological cancers, but its usefulness in the diagnosis of cancers of digestive organs has not been investigated. In this report, UGP was measured by sandwich enzyme immunoassay in 311 patients, including 166 patients with cancers of digestive organs and 43 healthy controls. Positive rates of UGP in various cancers of digestive organs were as follows: biliary tract 61.5%, pancreas 61.5%, esophagus 50.0%, liver 38.7%, colon and rectum 24.2%, and stomach 23.9%. The positive rate of UGP in benign diseases was 8.1%, and most false-positive patients were postmenopausal females. Positive rates of UGP were increased at advanced stages of gastric cancers, and UGP was decreased after tumor resection. From these results, it is suggested that UGP can be used as a tumor marker for the cancers of digestive organs.

• Authors: Y Motoo, H Watanabe, Y Yamaguchi, I Mouri, T Fujii, O Yamakawa, Y Satomura, T Okai, N Sawabu
• Journal: Anticancer research (Anticancer Res) 1996 Jul-Aug Vol. 16 Issue 4A Pg. 2041-8 ISSN: 0250-7005 [Print] Greece
• PMID: 8712740 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Biomarkers, Tumor
• CA-19-9 Antigen
• Carcinoembryonic Antigen
• Chorionic Gonadotropin
• Chorionic Gonadotropin, beta Subunit, Human
• Peptide Fragments
• urinary gonadotropin fragment
• Creatinine

Topics

• Aged
• Biomarkers, Tumor (urine)
• CA-19-9 Antigen (blood)
• Carcinoembryonic Antigen (blood)
• Chorionic Gonadotropin (analysis)
• Chorionic Gonadotropin, beta Subunit, Human (urine)
• Creatinine (blood, urine)
• Digestive System Neoplasms (blood, pathology, surgery, urine)
• Female
• Gallbladder Neoplasms (blood, pathology, surgery, urine)
• Humans
• Immunoenzyme Techniques
• Immunohistochemistry
• Male
• Middle Aged
• Neoplasm Staging
• Pancreatic Neoplasms (blood, pathology, surgery, urine)
• Peptide Fragments (urine)
• Reference Values
• Reproducibility of Results
• Sex Characteristics