Abstract |
A 76-year-old woman had lymphocytosis with lymphocytes having convoluted or lobulated nuclei. These abnormal lymphocytes (leukemic cells) were positive for CD4, and some expressed IL-2R (CD25) and CD3 molecules, respectively. These morphologic and phenotypic features were compatible with adult T-cell leukemia, but serum antibodies to human T-cell lymphotropic virus type I (HTLV-I) were not detected by the particle aggregation method and an enzyme-linked immunosorbent assay. The polymerase chain reaction showed that the LTR, gag, pol, and env regions of HTLV-I proviral DNA had not been incorporated into the leukemic cells. Only the pX region was detected in these leukemic cells.
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Authors | T Takenaka, K Kuribayashi, M Tsukiyama, H Nakamine, S Konami, K Okada |
Journal | Rinsho byori. The Japanese journal of clinical pathology
(Rinsho Byori)
Vol. 44
Issue 1
Pg. 81-4
(Jan 1996)
ISSN: 0047-1860 [Print] Japan |
PMID | 8691645
(Publication Type: Case Reports, Journal Article)
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Chemical References |
- CD4 Antigens
- DNA, Viral
- HTLV-I Antibodies
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Topics |
- Aged
- Base Sequence
- CD4 Antigens
(analysis)
- DNA, Viral
(genetics)
- Female
- Genes, Viral
- Genes, pX
- HTLV-I Antibodies
- Human T-lymphotropic virus 1
(genetics)
- Humans
- Leukemia, T-Cell
(virology)
- Molecular Sequence Data
- Polymerase Chain Reaction
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