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[Case of adult T-cell leukemia without antibodies for HTLV-I but with for pX gene region].

Abstract
A 76-year-old woman had lymphocytosis with lymphocytes having convoluted or lobulated nuclei. These abnormal lymphocytes (leukemic cells) were positive for CD4, and some expressed IL-2R (CD25) and CD3 molecules, respectively. These morphologic and phenotypic features were compatible with adult T-cell leukemia, but serum antibodies to human T-cell lymphotropic virus type I (HTLV-I) were not detected by the particle aggregation method and an enzyme-linked immunosorbent assay. The polymerase chain reaction showed that the LTR, gag, pol, and env regions of HTLV-I proviral DNA had not been incorporated into the leukemic cells. Only the pX region was detected in these leukemic cells.
AuthorsT Takenaka, K Kuribayashi, M Tsukiyama, H Nakamine, S Konami, K Okada
JournalRinsho byori. The Japanese journal of clinical pathology (Rinsho Byori) Vol. 44 Issue 1 Pg. 81-4 (Jan 1996) ISSN: 0047-1860 [Print] Japan
PMID8691645 (Publication Type: Case Reports, Journal Article)
Chemical References
  • CD4 Antigens
  • DNA, Viral
  • HTLV-I Antibodies
Topics
  • Aged
  • Base Sequence
  • CD4 Antigens (analysis)
  • DNA, Viral (genetics)
  • Female
  • Genes, Viral
  • Genes, pX
  • HTLV-I Antibodies
  • Human T-lymphotropic virus 1 (genetics)
  • Humans
  • Leukemia, T-Cell (virology)
  • Molecular Sequence Data
  • Polymerase Chain Reaction

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