[Prognostic factors of Pneumocystis carinii pneumonia in AIDS].

Abstract

OBJECTIVES:

Identify prognosis factors in Pneumocystis carinii pneumonia at diagnosis and construct a model to predict mortality according to these prognosis factors.

METHODS:

Seventy-seven consecutive cases of proven AIDS-related Pneumocystis carinii pneumonia (67 men, 10 women, mean age 37.2 years) were reviewed to determine the most accurate initial prognostic factors and estimate an individual prediction of death. A stepwise logistic regression analysis was performed. Three kinds of data were entered into the logistic model: historical data, clinical and laboratory data obtained within the first 24 hours of diagnosis, and specific data related to chest X-ray and bronchoalveolar lavage results.

RESULTS:

The sum of arterial partial pressure of oxygen and carbon dioxide (PaO2 + PaCO2) and serum albumin level best predicted a fatal outcome in multivariate analysis.

CONCLUSION:

The logistic equation provided by the model might be used to accurately and quickly identify the patients with severe Pneumocystis carinii pneumonia who might benefit from supportive intensive care.

• Authors: B Hoen, J F Viel, M Maignan, L Hennequin, T May, C Amiel, L Kures, P Canton
• Journal: Presse medicale (Paris, France : 1983) (Presse Med) Vol. 25 Issue 9 Pg. 443-8 (Mar 16 1996) ISSN: 0755-4982 [Print] France
• Vernacular Title: Facteurs pronostiques de la pneumocystose au cours du SIDA.
• PMID: 8685193 (Publication Type: English Abstract, Journal Article)

Chemical References

• Serum Albumin

Topics

• AIDS-Related Opportunistic Infections (blood, microbiology, mortality)
• Adult
• Aged
• Blood Gas Analysis
• Female
• Humans
• Logistic Models
• Male
• Middle Aged
• Pneumonia, Pneumocystis (blood, microbiology, mortality)
• Predictive Value of Tests
• Prognosis
• Retrospective Studies
• Sensitivity and Specificity
• Serum Albumin (analysis)