[DNA cytometry of solitary and aneurysmal bone cysts and low malignancy and high malignancy central osteosarcomas. Current significance within the scope of morphologic diagnosis of intraosseous cystic and osteoblastic lesions].

Abstract

DNA cytometric investigations of intraosseous cystic lesions and osteoblastic tumors may be helpful in morphological diagnosis. The detection of a DNA-aneuploid stemline supports the diagnosis of a high-grade malignant bone neoplasm, even in small biopsies. Solitary and aneurysmal bone cysts have DNA-diploid cell populations. Low-grade central osteosarcomas may show single-cell aneuploidies of varying extent as well as a DNA-diploid stemline. Their presence may be a sign of genetic instability within the population of neoplastic cells before a DNA-aneuploid stemline is established and should prompt careful postoperative observation.

• Authors: M Werner, A Heintz, G Delling
• Journal: Der Pathologe (Pathologe) Vol. 17 Issue 1 Pg. 44-9 (Jan 1996) ISSN: 0172-8113 [Print] Germany
• Vernacular Title: DNA-Zytometrie an solitären und aneurysmatischen Knochen-zysten sowie niedrigmalignen und hochmalignen zentralen Osteosarkomen. Gegenwärtige Bedeutung im Rahmen der morphologischen Diagnostik intraossärer zystischer und osteoblastischer Läsionen.
• PMID: 8685095 (Publication Type: English Abstract, Journal Article)

Chemical References

• DNA, Neoplasm

Topics

• Aneuploidy
• Bone Cysts (genetics, pathology)
• Bone Cysts, Aneurysmal (genetics, pathology)
• Bone Neoplasms (genetics, pathology)
• Cell Line
• Cell Transformation, Neoplastic (genetics, pathology)
• DNA, Neoplasm (analysis, genetics)
• Flow Cytometry
• Gene Expression Regulation, Neoplastic (physiology)
• Humans
• Neoplastic Stem Cells (pathology)
• Osteosarcoma (genetics, pathology)
• Prognosis