Abstract | PURPOSE: PATIENTS AND METHODS: RESULTS: Of 57 patients entered into the study, 54 were evaluable, representing 13.1 patient-years of observation. The 28 TMP-SMX patients and 26 control patients were comparable in terms of chemotherapy regimen, age, gender, stage, and bone marrow function. Bacterial infection during the 3-month study period occurred in 11 control patients but in only 2 patients assigned TMP-SMX (P = 0.004). Eight severe infections occurred in controls compared with 1 in a TMP-SMX patient (P = 0.010) leading to 4 and 1 infection deaths, respectively (P = not significant). Severe infections included 5 pneumonias (3 with sepsis), 2 urinary tract infections with complicating pneumonia or sepsis, 1 diverticulitis with perforation, and 1 staphylococcal scalded skin syndrome. None of the 4 nonbacterial infections was severe. The rate of bacterial infection was 2.43 per patient-year for controls and 0.29 per patient-year for the TMP-SMX group (P = 0.001). Toxicity ( skin rash 6 patients, nausea 1 patient) was not life-threatening but required discontinuation of TMP-SMX in 25% of patients. CONCLUSION:
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Authors | M M Oken, C Pomeroy, D Weisdorf, J M Bennett |
Journal | The American journal of medicine
(Am J Med)
Vol. 100
Issue 6
Pg. 624-8
(Jun 1996)
ISSN: 0002-9343 [Print] United States |
PMID | 8678082
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Anti-Infective Agents
- Trimethoprim, Sulfamethoxazole Drug Combination
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Topics |
- Aged
- Anti-Infective Agents
(adverse effects, therapeutic use)
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects)
- Bacterial Infections
(etiology, prevention & control)
- Female
- Humans
- Incidence
- Male
- Middle Aged
- Multiple Myeloma
(drug therapy)
- Time Factors
- Treatment Outcome
- Trimethoprim, Sulfamethoxazole Drug Combination
(adverse effects, therapeutic use)
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