New evidence for an inflammatory component in diarrhea caused by selected new, live attenuated cholera vaccines and by El Tor and Q139 Vibrio cholerae.

Abstract

Using a lactoferrin latex agglutination assay, we have compared the inflammatory responses to a cholera vaccine candidate, CVD 110, in which all known toxin genes have been deleted or mutated yet still produced significant diarrhea, with a less reactive vaccine strain and wild-type El Tor and 0139 Vibrio cholerae strains. Data suggest that diarrhea due to attenuated and wild-type El Tor V. cholerae, and to a lesser extent 0139 V. cholerae, involves an inflammatory response. Further study is required to further elucidate the mechanism of the process(es) involved.

• Authors: T M Silva, M A Schleupner, C O Tacket, T S Steiner, J B Kaper, R Edelman, R Guerrant
• Journal: Infection and immunity (Infect Immun) Vol. 64 Issue 6 Pg. 2362-4 (Jun 1996) ISSN: 0019-9567 [Print] United States
• PMID: 8675353 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Cholera Vaccines
• Vaccines, Attenuated
• Lactoferrin

Topics

• Cholera Vaccines (adverse effects)
• Diarrhea (etiology)
• Humans
• Inflammation (etiology)
• Lactoferrin (analysis)
• Neutrophils (physiology)
• Vaccines, Attenuated (adverse effects)
• Vibrio cholerae (pathogenicity)