Abstract | BACKGROUND: METHODS AND RESULTS: The effect of intracoronary infusion of L-arginine (50 mg/mm) on acetylcholine-induced coronary vasomotion was studied in eight patients with microvascular angina and eight control subjects. The responses of the large epicardial coronary artery diameter and coronary blood flow were measured with coronary arteriography and an intracoronary Doppler catheter, respectively. Acetylcholine increased coronary blood flow with modest vasoconstriction of the large coronary artery without altering arterial pressure and heart rate. The acetylcholine-induced increases in coronary blood flow were significantly less (P < .01) in patients than in control subjects. L-Arginine significantly augmented the coronary blood flow responses to acetylcholine in patients, but not in control subjects. L-Arginine did not alter responses of the large coronary artery in either group. CONCLUSIONS: Study results suggest that L-arginine improved endothelium-dependent vasodilation of coronary microcirculation in patients with microvascular angina pectoris.
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Authors | K Egashira, Y Hirooka, T Kuga, M Mohri, A Takeshita |
Journal | Circulation
(Circulation)
Vol. 94
Issue 2
Pg. 130-4
(Jul 15 1996)
ISSN: 0009-7322 [Print] United States |
PMID | 8674170
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Nitric Oxide
- Arginine
- Acetylcholine
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Topics |
- Acetylcholine
(pharmacology)
- Adult
- Aged
- Angina Pectoris
(physiopathology)
- Arginine
(pharmacology)
- Coronary Angiography
- Coronary Vessels
(drug effects, physiology)
- Female
- Humans
- Male
- Middle Aged
- Nitric Oxide
(physiology)
- Vasodilation
(drug effects, physiology)
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