Abstract | OBJECTIVE: The aim of this study was to investigate: 1. Whether the perioperative administration of metamizol causes a significant reduction in postoperative opioid requirements within the first 24 h after surgery. 2. The opioid-sparing effect after different types of operations. 3. Whether preoperative application of metamizol causes a significant reduction of the pain-score immediately after operation. METHODS: In a double-blind, randomised, placebo-controlled study, 117 patients, scheduled for minor orthopaedic or laparoscopic surgery or other operations (mainly resection of the thyroid gland and inguinal herniotomies) received either metamizol (1 g/100 ml NaCl 0.9%) or placebo (100 ml NaCl 0.9%) intravenously over 15 min in three separate doses: the first dose was given just before induction and the others 6 h and 12 h later. After surgery all patients were allowed to self-administer buprenorphine from a PCA ( patient-controlled analgesia) pump (Bolus: 30 microgram, lockout: 5 min in the recovery room, 30 min on the ward). Every hour for the first 6 h and after 24 h, cumulated doses of buprenorphine, pain scores (0-10), blood pressure, pulse and side effects were recorded. RESULTS: After minor orthopaedic and laparoscopic surgery, metamizol-treated patients had significantly less pain immediately after surgery and used a significantly lower cumulated dose of opioid in the first 24 h after surgery (-20% and -67% respectively) than patients receiving placebo. After the other types of surgery no analgesic effect could be established. CONCLUSIONS: Perioperative administration of metamizol results in better pain relief and significantly lower buprenorphine requirements particularly after laparoscopic operations. To achieve a significant pain reduction immediately after the operation, the first dose should be applied before induction.
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Authors | P Steffen, I Schuhmacher, T Weichel, M Georgieff, W Seeling |
Journal | Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS
(Anasthesiol Intensivmed Notfallmed Schmerzther)
Vol. 31
Issue 3
Pg. 143-7
(Apr 1996)
ISSN: 0939-2661 [Print] Germany |
Vernacular Title | Untersuchungen zum differenzierten Einsatz von Nichtopioiden zur postoperativen Analgesie I. Quantifizierung des analgetischen Effektes von Metamizol mittels der patientenkontrollierten Analgesie. |
PMID | 8672615
(Publication Type: Clinical Trial, Comparative Study, English Abstract, Journal Article, Randomized Controlled Trial)
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Chemical References |
- Anti-Inflammatory Agents, Non-Steroidal
- Dipyrone
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Topics |
- Adolescent
- Adult
- Aged
- Analgesia, Patient-Controlled
- Anti-Inflammatory Agents, Non-Steroidal
(administration & dosage, adverse effects)
- Dipyrone
(administration & dosage, adverse effects)
- Dose-Response Relationship, Drug
- Double-Blind Method
- Drug Administration Schedule
- Female
- Humans
- Male
- Middle Aged
- Pain Measurement
- Pain, Postoperative
(drug therapy, etiology)
- Preanesthetic Medication
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