Expression of catenins in human cancer cells and its regulation by n-6 polyunsaturated fatty acids.

Abstract	Catenins (alpha, beta, and gamma) are a group of proteins linking E-cadherin with the cytoskeleton. Reduced expression of alpha catenin has been shown in some cancer lines and tissues and is related to the invasive nature of tumour cells. This study examined the effects of n-6 PUFAs on the expression of catenins in a range of human cancer cells by Western blotting. Although most of the cell lines expressed similar levels of beta and gamma catenins, a number of cell lines expressed low levels of alpha catenin. Treatment of cells with gamma linolenic acid (GLA) increased alpha catenin expression in most cell lines, while beta catenin levels were reduced, and gamma catenin expression was unchanged. Linoleic acid and arachidonic acid had not significant effects. We conclude that in human cancer cell lines, the expression of alpha and beta catenins can be regulated by gamma linolenic acid.
Authors	W G Jiang, S Hiscox, D F Horrobin, M B Hallett, R E Mansel, M C Puntis
Journal	Anticancer research (Anticancer Res) 1995 Nov-Dec Vol. 15 Issue 6B Pg. 2569-73 ISSN: 0250-7005 [Print] Greece
PMID	8669825 (Publication Type: Comparative Study, Journal Article)
Chemical References	CTNNA1 protein, human CTNNB1 protein, human Cytoskeletal Proteins Desmoplakins Fatty Acids, Omega-6 Fatty Acids, Unsaturated JUP protein, human Linoleic Acids Neoplasm Proteins Trans-Activators alpha Catenin beta Catenin gamma Catenin Arachidonic Acid gamma-Linolenic Acid Linoleic Acid
Topics	Arachidonic Acid (pharmacology) Blotting, Western Cytoskeletal Proteins (biosynthesis, genetics) Desmoplakins Fatty Acids, Omega-6 Fatty Acids, Unsaturated (pharmacology) Gene Expression Regulation, Neoplastic (drug effects) Humans Linoleic Acid Linoleic Acids (pharmacology) Neoplasm Invasiveness Neoplasm Proteins (biosynthesis, genetics) Neoplasms (genetics, metabolism, pathology) Trans-Activators Tumor Cells, Cultured alpha Catenin beta Catenin gamma Catenin gamma-Linolenic Acid (pharmacology)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.

Realize the full power of the drug-disease research graph!