Abstract | PURPOSE: METHODS: RESULTS: With a mean follow-up of 143 days (range, 10 to 608 days), we achieved successful ocular surface reconstruction in 12 eyes, with minimal recurrence of symblepharon. Failure occurred in two eyes (one each in 9- and 10-year-old boys) that developed corneal infiltration and vascularization. CONCLUSIONS: A combination of allograft limbal transplantation, amniotic membrane transplantation, and tarsorrhaphy, followed by the use of serum-derived tears, can reconstruct the ocular surface in most cases. Although in this study the follow-up period was short and relatively few patients were studied, this approach appears to offer an alternative to keratoprosthesis for treating severe cicatricial keratoconjunctivitis with dry eye.
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Authors | K Tsubota, Y Satake, M Ohyama, I Toda, Y Takano, M Ono, N Shinozaki, J Shimazaki |
Journal | American journal of ophthalmology
(Am J Ophthalmol)
Vol. 122
Issue 1
Pg. 38-52
(Jul 1996)
ISSN: 0002-9394 [Print] United States |
PMID | 8659597
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Biological Dressings
- Cell Transplantation
- Child
- Corneal Opacity
(surgery)
- Epithelium
(transplantation)
- Eyelids
(surgery)
- Female
- Humans
- Keratoconjunctivitis
(pathology, surgery)
- Keratoplasty, Penetrating
- Limbus Corneae
(cytology)
- Male
- Middle Aged
- Ophthalmic Solutions
(administration & dosage)
- Pemphigoid, Benign Mucous Membrane
(pathology, surgery)
- Prospective Studies
- Stevens-Johnson Syndrome
(pathology, surgery)
- Transplantation, Homologous
- Visual Acuity
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