Hepatocellular carcinoma: MR imaging with mangafodipir trisodium (Mn-DPDP).

Abstract

PURPOSE:

To determine the efficacy of manganese (II) N,N'-dipyridoxylethylenediamine-N,N'-diacetate 5,5'-bis(phosphate) (DPDP) at magnetic resonance (MR) imaging for evaluation of hepatocellular carcinoma (HCC).

MATERIALS AND METHODS:

MR imaging at 1.5 T was performed in 20 patients with 65 HCC nodules. T1- and T2-weighted spin-echo and T1-weighted gradient-recalled-echo images were obtained before and after administration of 5 mumol/kg Mn-DPDP. Readers individually evaluated the pre- and postcontrast images for detection of tumor nodules, with subsequent consensus reading for interpretation discrepancies. Quantitative measurements of tumor-liver contrast-to-noise ratio (C/N) were also performed. Enhancement characteristics were correlated with histologic tumor differentiation.

RESULTS:

Precontrast images depicted 50 lesions in 17 patients, and postcontrast images depicted 49 lesions in 20 patients. Combination of pre- and postcontrast images enabled detection of 53 lesions in 20 patients. Three lesions (three patients) were seen only on postcontrast images. Four lesions (three patients) were seen only on precontrast images. Reader evaluation of tumor conspicuity showed a significant preference for precontrast T2-weighted SE images (P < .01). Quantitative evaluation showed a significant increase in C/N on postcontrast T1-weighted images (P < .01). Well-differentiated lesions showed significantly greater enhancement than that of poorly differentiated lesions (P < .05).

CONCLUSION:

Mn-DPDP-enhanced MR imaging depicts HCC tumors not visualized with unenhanced studies. The degree of tumor enhancement correlates with histologic differentiation.

• Authors: T Murakami, R L Baron, M S Peterson, J H Oliver 3rd, P L Davis, S R Confer, M P Federle
• Journal: Radiology (Radiology) Vol. 200 Issue 1 Pg. 69-77 (Jul 1996) ISSN: 0033-8419 [Print] United States
• PMID: 8657947 (Publication Type: Clinical Trial, Clinical Trial, Phase III, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Contrast Media
• Manganese
• Pyridoxal Phosphate
• Edetic Acid
• N,N'-bis(pyridoxal-5-phosphate)ethylenediamine-N,N'-diacetic acid

Topics

• Adult
• Aged
• Aged, 80 and over
• Carcinoma, Hepatocellular (diagnosis, pathology)
• Confidence Intervals
• Contrast Media
• Edetic Acid (analogs & derivatives)
• Female
• Humans
• Liver (pathology)
• Liver Neoplasms (diagnosis, pathology)
• Magnetic Resonance Imaging
• Male
• Manganese
• Middle Aged
• Pyridoxal Phosphate (analogs & derivatives)