[Occurrence of TSH receptor antibodies and thyroid microsomal antibodies in Graves-Basedow disease].

Abstract

Anti-TSH receptor antibody examination was performed in patients with Basedow-Graves' disease (141 patient: 34 before treatment, 49 during medicamentous therapy, 55 in stable remission and 3 with spontaneous hypothyroidism). The following findings were found: anti-TSH receptor antibodies were positive in 87% of untreated patients; in patients with medicamentous therapy they are in correlation with the metabolic status of the patients; only in 2% of patients in remission findings were high; all of the three patients with spontaneous hypothyroidism have had high titer. Findings of the thyroid microsomal antibodies don't have such regularity: the results were high in 67% of untreated patients; were in correlation with functional status during therapy; highly present in remission (62%) and have high titers in spontaneous hypothyroidism. The gathered results confirm opinions that anti-TSH receptor antibodies are highly etiopathogenetically significant in autoimmune hypothyroidism, but underline that the finding of thyroid microsomal antibodies is not clear enough.

• Authors: N Paunković, D Paunković
• Journal: Medicinski pregled (Med Pregl) Vol. 48 Issue 1-2 Pg. 10-4 ( 1995) ISSN: 0025-8105 [Print] Serbia
• Vernacular Title: Ucestalost nalaza antitela na TSH receptore i tireoidnih mikrozomskih antitela u Graves-Bazedovljevoj bolesti.
• PMID: 8657049 (Publication Type: English Abstract, Journal Article)

Chemical References

• Autoantibodies
• Receptors, Thyrotropin
• thyroid microsomal antibodies

Topics

• Autoantibodies (analysis, immunology)
• Graves Disease (drug therapy, immunology)
• Humans
• Receptors, Thyrotropin (immunology)