Abstract | OBJECTIVES: DESIGN: SETTING: The study was performed at the thyroid outpatient units of two general hospitals, with the patients having been referred from primary care. SUBJECTS: INTERVENTIONS: The patients were allocated into six groups. Three groups received methimazole (10 mg every 6th, 8th or 12th h) and three received propylthiouracil (100 mg every 6th, 8th or 12th h). Twenty micrograms of triiodothyronine was added when the patients were euthyroid to avoid hypothyroidism. MAIN OUTCOME MEASURES: The lowest serum free thyroxine level within 3 months of the initiation of the antithyroid treatment. RESULTS: Fourteen per cent of the patients on methimazole 10 mg every 12th h and 29% on propylthiouracil 100 mg every 12th h did not achieve euthyroidism within the 3-month observation period. All but one patient on methimazole 10 mg every 8th h or propylthiouracil 100 mg every 8th h reduced the free serum thyroxine levels to the normal or hypothyroid range within the observation period. All of the patients on methimazole 10 mg every 6th h and 56% on propylthiouracil 100 mg every 6th h reduced the serum T4 values into the hypothyroid range within the period. CONCLUSION:
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Authors | G Kallner, S Vitols, J G Ljunggren |
Journal | Journal of internal medicine
(J Intern Med)
Vol. 239
Issue 6
Pg. 525-9
(Jun 1996)
ISSN: 0954-6820 [Print] England |
PMID | 8656146
(Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antithyroid Agents
- Methimazole
- Propylthiouracil
- Thyroxine
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Topics |
- Adolescent
- Adult
- Aged
- Antithyroid Agents
(administration & dosage, therapeutic use)
- Drug Administration Schedule
- Drug Therapy, Combination
- Female
- Graves Disease
(blood, drug therapy)
- Humans
- Male
- Methimazole
(administration & dosage, therapeutic use)
- Middle Aged
- Propylthiouracil
(administration & dosage, therapeutic use)
- Prospective Studies
- Thyroxine
(blood, drug effects)
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