Abstract | BACKGROUND: METHODS AND RESULTS: Southern blotting and polymerase chain reaction analysis of somatic cell hybrids and fluorescence in situ hybridization (FISH) of metaphase chromosomes were used to assess the chromosomal localization of VEGF-B and VEGF-C genes. The VEGF-B gene was found on chromosome 11q13, proximal to the cyclin D1 gene, which is amplified in a number of human carcinomas. However, VEGF-B was not amplified in several mammary carcinoma cell lines containing amplified cyclin D1. The VEGF-C gene was located on chromosome 4q34, close to the human aspartylglucosaminidase gene previously mapped to 4q34-35. CONCLUSIONS:
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Authors | K Paavonen, N Horelli-Kuitunen, D Chilov, E Kukk, S Pennanen, O P Kallioniemi, K Pajusola, B Olofsson, U Eriksson, V Joukov, A Palotie, K Alitalo |
Journal | Circulation
(Circulation)
Vol. 93
Issue 6
Pg. 1079-82
(Mar 15 1996)
ISSN: 0009-7322 [Print] United States |
PMID | 8653826
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Endothelial Growth Factors
- Lymphokines
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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Topics |
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 11
- Chromosomes, Human, Pair 4
- Endothelial Growth Factors
(genetics)
- Humans
- Lymphokines
(genetics)
- Molecular Sequence Data
- Tumor Cells, Cultured
- Vascular Endothelial Growth Factor A
- Vascular Endothelial Growth Factors
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