Abstract | BACKGROUND: Converting enzyme inhibition (CEI) ameliorates progressive loss of function in non-immune-mediated renal diseases and experimental hypertension. Little, however, is known on the potential role of CEI in established experimental chronic glomerular immune injury. We therefore studied the effect of the CEI ramipril on renal function and morphology in a model of immune mediated glomerular injury. METHODS: RESULTS: CONCLUSIONS: These data demonstrate that ramipril reduced albuminuria in a model of immune complex glomerulonephritis; however, it failed to alter GFR and glomerular damage index. The study suggests that ramipril ameliorates proteinuria independently of obvious glomerular histological changes. The reduction of proteinuria is, however, associated with a significant decrease in filtration fraction and therefore is at least partially haemodynamically mediated.
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Authors | F Thaiss, C Haas, U Helmchen, U Wenzel, R A Stahl |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 11
Issue 1
Pg. 40-6
(Jan 1996)
ISSN: 0931-0509 [Print] England |
PMID | 8649651
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Angiotensin-Converting Enzyme Inhibitors
- Lipids
- Serum Albumin
- Renin
- Ramipril
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Topics |
- Albuminuria
(drug therapy, metabolism)
- Analysis of Variance
- Angiotensin-Converting Enzyme Inhibitors
(pharmacology)
- Animals
- Glomerulonephritis
(drug therapy, metabolism, pathology)
- Kidney
(drug effects, pathology)
- Kidney Function Tests
- Lipids
(blood)
- Male
- Organ Size
- Ramipril
(pharmacology)
- Rats
- Rats, Wistar
- Renin
(blood, drug effects)
- Serum Albumin
(metabolism)
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