Abstract | BACKGROUND: METHODS: We studied seven critically ill patients with ARF before, during and after continuous veno-venous haemofiltration (CVVH) with AN69. RESULTS: There was a rapid decrease of factor D levels to 62(+/-6%) of the pre-CVVH value during the first 2 h, which continued to 51(+/-7.3%) after 12 h; at 24 h there was a slight rise to 62 +/- 12%. Sequential use of Polyacrylonitrile (AN69) filters lowered factor D levels below the normal plasma concentration in three patients, thus producing a state of factor D depletion. CONCLUSION: The significant reduction of factor D levels during CVVH with PAN filters suggests that frequent changes of PAN filters may reduce alternative pathway function by lowering factor D levels. CVVH (as opposed to intermittent dialysis) with PAN membranes may further improve the outcome of critically ill patients.
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Authors | Y Gasche, M Pascual, P M Suter, H Favre, J C Chevrolet, J A Schifferli |
Journal | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association
(Nephrol Dial Transplant)
Vol. 11
Issue 1
Pg. 117-9
(Jan 1996)
ISSN: 0931-0509 [Print] England |
PMID | 8649617
(Publication Type: Journal Article)
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Chemical References |
- Acrylic Resins
- Growth Inhibitors
- Interleukin-6
- LIF protein, human
- Leukemia Inhibitory Factor
- Lymphokines
- Membranes, Artificial
- polyacrylonitrile
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Topics |
- Acrylic Resins
- Acute Kidney Injury
(blood, therapy)
- Adult
- Aged
- Aged, 80 and over
- Complement Activation
(physiology)
- Growth Inhibitors
(blood)
- Hemofiltration
(instrumentation)
- Humans
- Interleukin-6
- Leukemia Inhibitory Factor
- Lymphokines
(blood)
- Membranes, Artificial
- Middle Aged
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