Microsporidial keratoconjunctivitis caused by Septata intestinalis in a patient with acquired immunodeficiency syndrome.

Abstract

PURPOSE:

To examine and treat a patient with acquired immunodeficiency syndrome (AIDS) who had mildly hyperemic conjunctiva and epithelial keratopathy in both eyes.

METHODS:

The patient underwent conjunctival biopsy. The specimen was examined by transmission electron microscopy.

RESULTS:

Septata intestinalis was demonstrated to be the cause of keratoconjunctivitis in the patient. The keratoconjunctivitis resolved after three weeks of therapy with topical fumagillin. No organisms were seen on repeat conjunctival biopsy.

CONCLUSIONS:

Microsporidial keratoconjunctivitis in patients with AIDS can be caused by S. intestinalis. This condition appears to respond to topical fumagillin.

• Authors: C Y Lowder, J T McMahon, D M Meisler, E M Dodds, L H Calabrese, E S Didier, A Cali
• Journal: American journal of ophthalmology (Am J Ophthalmol) Vol. 121 Issue 6 Pg. 715-7 (Jun 1996) ISSN: 0002-9394 [Print] United States
• PMID: 8644819 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antiprotozoal Agents
• Cyclohexanes
• Fatty Acids, Unsaturated
• Ophthalmic Solutions
• Sesquiterpenes
• fumagillin

Topics

• AIDS-Related Opportunistic Infections (drug therapy, etiology, parasitology)
• Administration, Topical
• Adult
• Animals
• Antiprotozoal Agents (therapeutic use)
• Biopsy
• Conjunctiva (parasitology, pathology)
• Cyclohexanes
• Epithelium (parasitology, pathology)
• Eye Infections, Parasitic (drug therapy, etiology, parasitology)
• Fatty Acids, Unsaturated (therapeutic use)
• Feces (parasitology)
• Humans
• Intestinal Diseases, Parasitic (drug therapy, etiology)
• Keratoconjunctivitis (drug therapy, parasitology)
• Male
• Microsporida (isolation & purification, ultrastructure)
• Microsporidiosis (drug therapy, etiology, parasitology)
• Ophthalmic Solutions
• Sesquiterpenes