Abstract | BACKGROUND: METHODS: In the phrenic-diaphragm preparation, mivacurium was administered to obtain >90% single twitch inhibition. Single twitch responses (0.1 Hz) were monitored for 60 min, after which the response to train-of-four stimulation was tested. The reversal of mivacurium by 0.5, 1.0, or 2.0 units/ml of (true) acetylcholinesterase, bovine pseudocholinesterase, or human plasma cholinesterase and by neostigmine, 0.1, 1.0, or 10.0 micrograms/ml tested. The efficacy of human plasma cholinesterase, 1 unit/ml in combination with each of the above neostigmine concentrations, also was examined. The reversal of succinylcholine-induced paralysis by the acetylcholinesterase, bovine pseudocholinesterase, or human plasma cholinesterase (1 unit/ml) alone and in the presence of neostigmine (10.0 micrograms/ml) was additionally tested as a positive control. A train-of-four ratio > 0.75 was considered adequate reversal. RESULTS: CONCLUSIONS:
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Authors | H S Yang, N Goudsouzian, J A Martyn |
Journal | Anesthesiology
(Anesthesiology)
Vol. 84
Issue 4
Pg. 936-44
(Apr 1996)
ISSN: 0003-3022 [Print] United States |
PMID | 8638849
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)
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Chemical References |
- Cholinesterase Inhibitors
- Isoquinolines
- Neuromuscular Nondepolarizing Agents
- Neostigmine
- Mivacurium
- Butyrylcholinesterase
- Succinylcholine
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Topics |
- Animals
- Butyrylcholinesterase
(physiology)
- Cattle
- Cholinesterase Inhibitors
(pharmacology)
- Humans
- Hydrolysis
- In Vitro Techniques
- Isoquinolines
(metabolism, pharmacology)
- Male
- Mivacurium
- Neostigmine
(pharmacology)
- Neuromuscular Junction
(drug effects)
- Neuromuscular Nondepolarizing Agents
(metabolism)
- Rats
- Rats, Sprague-Dawley
- Succinylcholine
(metabolism, pharmacology)
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