[Eight days of naproxen therapy can prevent heterotopic ossification after total hip alloplasty].

Abstract

The effect of one week of treatment with naproxen on the formation of heterotopic ossification after cemented total hip arthroplasty was studied in a prospective trial. Twenty-seven patients received 500 mg naproxen twice daily for seven days postoperatively. The medication was started on the morning of the operation. The results were compared to a control group of 23 patients from a previous study who had not received any kind of nonsteroidal anti-inflammatory drug. All radiographs were randomly mixed and patient identification was blinded. Three months after the operation 12/23 patients in the control group and 3/27 in the naproxen-treated group had developed heterotopic ossification. One year after the operation 4/27 in the naproxen-treated group and 12/23 in the control group had heterotopic ossification (p < 0.05). Three patients in the control group and none in the naproxen-treated group developed severe ossification. It is concluded that naproxen given for one week can decrease the incidence of heterotopic ossification after total hip arthroplasty.

• Authors: P H Gebuhr, H Wilbek, M Soelberg
• Journal: Ugeskrift for laeger (Ugeskr Laeger) Vol. 158 Issue 8 Pg. 1076-8 (Feb 19 1996) ISSN: 0041-5782 [Print] Denmark
• Vernacular Title: Otte dages behandling med naproxen kan forebygge heterotop forkalkning efter total hoftealloplastik.
• PMID: 8638341 (Publication Type: Clinical Trial, Comparative Study, Controlled Clinical Trial, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Naproxen

Topics

• Aged
• Anti-Inflammatory Agents, Non-Steroidal (administration & dosage)
• Female
• Hip Prosthesis (adverse effects)
• Humans
• Male
• Middle Aged
• Naproxen (administration & dosage)
• Ossification, Heterotopic (diagnostic imaging, etiology, prevention & control)
• Postoperative Complications (diagnostic imaging, prevention & control)
• Radiography