Intravenous pamidronate for hypercalcemia of primary hyperparathyroidism.

Abstract	Intravenous pamidronate disodium has been used successfully in the treatment of malignancy-associated hypercalcemia and Paget's disease of bone. Although the definitive treatment of primary hyperparathyroidism (PHPT) is surgical, intravenous pamidronate has been used to treat hypercalcemia of PHPT when surgery was contraindicated. We report two cases of PHPT in which intravenous pamidronate effectively reduced hypercalcemia and significantly improved the clinical symptoms. The results of our study and the experience in the literature suggest that pamidronate is a safe and effective method of reducing serum calcium in patients with PHPT when definitive surgery is contraindicated or must be postponed.
Authors	A Tal, L Graves
Journal	Southern medical journal (South Med J) Vol. 89 Issue 6 Pg. 637-40 (Jun 1996) ISSN: 0038-4348 [Print] United States
PMID	8638211 (Publication Type: Case Reports, Journal Article)
Chemical References	Diphosphonates Parathyroid Hormone Pamidronate Calcium
Topics	Aged Calcium (blood) Diphosphonates (administration & dosage, therapeutic use) Female Humans Hypercalcemia (blood, drug therapy, etiology) Hyperparathyroidism (blood, complications) Infusions, Intravenous Male Middle Aged Pamidronate Parathyroid Hormone (blood)

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