Abstract | OBJECTIVES: This study sought to determine whether the reopening of the infarct-related vessel is related to clinical characteristics or cardiovascular risk factors, or both. BACKGROUND: METHODS: RESULTS: Thrombolysis in current smokers and anterior infard location on admission were the three independent factors highly correlated with the patency of the infarct-related vessel (odds ratios 3.2, 3.0 and 1.9, respectively). In smokers, thrombolytic therapy was associated with a higher reopening rate of the infard vessel, from 35% to 77% (p < 0.001). Nonsmokers did not benefit from thrombolytic therapy, regardless of infarct location. CONCLUSIONS: These observational data, if replicated, suggest that in patients with acute myocardial infarction, thrombolytic therapy may be most effective in current smokers, whereas nonsmokers and ex-smokers may require other management strategies, such as emergency percutaneous transluminal coronary angioplasty.
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Authors | C de Chillou, P Riff, N Sadoul, G Ethevenot, L Feldmann, K Isaaz, J P Simon, M Boursier, K Khalifé, J Y Thisse, E Aliot |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 27
Issue 7
Pg. 1662-8
(Jun 1996)
ISSN: 0735-1097 [Print] United States |
PMID | 8636551
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Streptokinase
- Plasminogen Activators
- Tissue Plasminogen Activator
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Topics |
- Aged
- Female
- Humans
- Male
- Middle Aged
- Myocardial Infarction
(drug therapy)
- Plasminogen Activators
(therapeutic use)
- Recurrence
- Risk Factors
- Smoking
(adverse effects)
- Streptokinase
(therapeutic use)
- Stroke Volume
- Thrombolytic Therapy
- Tissue Plasminogen Activator
(therapeutic use)
- Treatment Failure
- Vascular Patency
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