Abstract | OBJECTIVES: BACKGROUND: METHODS: The study was designed as a randomized crossover, double-blind, placebo-controlled trial: 22 patients were assigned to 1 week each of nocturnal oxygen and room air. After each week, polysomnography, maximal bicycle exercise with expiratory gas analysis and trail-making test were performed, and a health assessment chart was completed. RESULTS: Nocturnal oxygen significantly reduced the duration of Cheyne-Stokes respiration (162 +/- 142 vs. 88 +/- 105 min [mean +/- SD]; p < 0.005). Sleep improved as evidenced by less stage 1 sleep and fewer arousals (20 +/- 13 vs. 15 +/- 9/h total sleep time; p < 0.05) as well as more stage 2 and slow-wave sleep; nocturnal oxygen saturation also improved. Peak oxygen consumption during exercise testing increased after oxygen treatment (835 +/- 395 vs. 960 +/- 389 ml/min; p < 0.05). Cognitive function evaluated by the trail-making test improved, but daytime symptoms in the health assessment chart did not improve significantly. CONCLUSIONS:
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Authors | S Andreas, C Clemens, H Sandholzer, H R Figulla, H Kreuzer |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 27
Issue 6
Pg. 1486-90
(May 1996)
ISSN: 0735-1097 [Print] United States |
PMID | 8626963
(Publication Type: Clinical Trial, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Topics |
- Adult
- Aged
- Cheyne-Stokes Respiration
(etiology, physiopathology, therapy)
- Cognition
- Double-Blind Method
- Echocardiography
- Exercise Test
- Exercise Tolerance
- Heart Failure
(complications)
- Humans
- Middle Aged
- Oxygen Inhalation Therapy
- Polysomnography
- Sleep Wake Disorders
(therapy)
- Spirometry
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