Abstract | OBJECTIVES: BACKGROUND: Several clinical trials and overview analyses have suggested that the survival benefit conferred by thrombolytic therapy may be offset by a paradoxic increase in early deaths from cardiac rupture. METHODS: Demographic, procedural and outcome data from patients with acute myocardial infarction were collected at 1,073 United States hospitals collaborating in the United States National Registry of Myocardial Infarction. RESULTS: Among the 350,755 patients enrolled, 122,243 received thrombolytic therapy. In-hospital mortality for the overall patient population, those not treated with thrombolytics (n = 228,512) and those given thrombolytics were 10.4%, 12.9% and 5.9%, respectively (p<0.001). Cardiogenic shock was the most common cause of death in each patient group. Although the incidence of cardiac rupture was low (<1.0%), it was responsible for 7.3%, 6.1% and 12.1%, respectively, of in-hospital deaths (p<0.001). Death from rupture occurred earlier in patients given thrombolytic therapy, with a clustering of events within 24 h of drug administration. Despite the early risk, death rates were comparatively low in thrombolytic-treated patients on each of the first 30 days. By multivariable analysis, thrombolytics, prior myocardial infarction, advancing age, female gender and intravenous beta-blocker use were independently associated with cardiac rupture. CONCLUSIONS:
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Authors | R C Becker, J M Gore, C Lambrew, W D Weaver, R M Rubison, W J French, A J Tiefenbrunn, L J Bowlby, W J Rogers |
Journal | Journal of the American College of Cardiology
(J Am Coll Cardiol)
Vol. 27
Issue 6
Pg. 1321-6
(May 1996)
ISSN: 0735-1097 [Print] United States |
PMID | 8626938
(Publication Type: Journal Article)
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Topics |
- Age Factors
- Aged
- Female
- Heart Rupture, Post-Infarction
(mortality)
- Humans
- Male
- Multivariate Analysis
- Myocardial Infarction
(drug therapy, mortality)
- Registries
- Sex Factors
- Shock, Cardiogenic
(mortality)
- Thrombolytic Therapy
(adverse effects)
- United States
(epidemiology)
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