Abstract |
The tumorigenicity of 7-chlorobenz[a] anthracene (7-Cl-BA, and environmental contaminant, and 7 bromobenz[a] anthracene (7-Br-BA) was determines in the male B6C3F(1) newborn mouse. Mice receiving 7-Cl-BA and 7-Br-BA by i.p. injections at a dose of 1600 nmol per mouse on 1, 8, and 15 days after birth developed 92 and 96% hepatocellular adenomas, and 100 and 83% hepatocellular carcinoma, respectively. Metabolism by liver microsomes of 15-day-old mice each produced the corresponding trans-3,4- dihydrodiol. Analysis by (32)P-postlabeling/HPLC indicated the presence of DNA adducts derived from 7-Cl-BA trans-3,4- dihydrodiol and 7-Br-BA trans-3,4- dihydrodiol. Our results indicate that both 7-Cl-BA and 7-Br-BA are potent carcinogens and that bay-region diol epoxides are the ultimate metabolites that lead to DNA adduct formation and tumor initiation.
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Authors | P P Fu, L S Von Tungeln, D J Zhan, T Bucci |
Journal | Cancer letters
(Cancer Lett)
Vol. 101
Issue 1
Pg. 37-42
(Mar 19 1996)
ISSN: 0304-3835 [Print] Ireland |
PMID | 8625280
(Publication Type: Journal Article)
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Chemical References |
- Anthracenes
- Benz(a)Anthracenes
- Carcinogens
- DNA Adducts
- 7-chlorobenz(a)anthracene
- 7-bromobenzanthracene
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Topics |
- Animals
- Animals, Newborn
- Anthracenes
(metabolism, pharmacokinetics, toxicity)
- Benz(a)Anthracenes
(metabolism, pharmacokinetics, toxicity)
- Biotransformation
- Carcinogens
(pharmacokinetics, toxicity)
- DNA Adducts
(metabolism)
- Liver Neoplasms, Experimental
(chemically induced)
- Male
- Mice
- Microsomes, Liver
(metabolism)
- Specific Pathogen-Free Organisms
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