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Potent tumorigenicity of 7-chlorobenz[a]anthracene and 7-bromobenz[a]anthracene in the neonatal B6C3F (1) male mouse.

Abstract
The tumorigenicity of 7-chlorobenz[a]anthracene (7-Cl-BA, and environmental contaminant, and 7 bromobenz[a]anthracene (7-Br-BA) was determines in the male B6C3F(1) newborn mouse. Mice receiving 7-Cl-BA and 7-Br-BA by i.p. injections at a dose of 1600 nmol per mouse on 1, 8, and 15 days after birth developed 92 and 96% hepatocellular adenomas, and 100 and 83% hepatocellular carcinoma, respectively. Metabolism by liver microsomes of 15-day-old mice each produced the corresponding trans-3,4-dihydrodiol. Analysis by (32)P-postlabeling/HPLC indicated the presence of DNA adducts derived from 7-Cl-BA trans-3,4-dihydrodiol and 7-Br-BA trans-3,4-dihydrodiol. Our results indicate that both 7-Cl-BA and 7-Br-BA are potent carcinogens and that bay-region diol epoxides are the ultimate metabolites that lead to DNA adduct formation and tumor initiation.
AuthorsP P Fu, L S Von Tungeln, D J Zhan, T Bucci
JournalCancer letters (Cancer Lett) Vol. 101 Issue 1 Pg. 37-42 (Mar 19 1996) ISSN: 0304-3835 [Print] Ireland
PMID8625280 (Publication Type: Journal Article)
Chemical References
  • Anthracenes
  • Benz(a)Anthracenes
  • Carcinogens
  • DNA Adducts
  • 7-chlorobenz(a)anthracene
  • 7-bromobenzanthracene
Topics
  • Animals
  • Animals, Newborn
  • Anthracenes (metabolism, pharmacokinetics, toxicity)
  • Benz(a)Anthracenes (metabolism, pharmacokinetics, toxicity)
  • Biotransformation
  • Carcinogens (pharmacokinetics, toxicity)
  • DNA Adducts (metabolism)
  • Liver Neoplasms, Experimental (chemically induced)
  • Male
  • Mice
  • Microsomes, Liver (metabolism)
  • Specific Pathogen-Free Organisms

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