Transforming growth factor-beta fails to inhibit allograft rejection or virus-induced autoimmune diabetes in transgenic mice.

Abstract

Transgenic mice whose pancreata express transforming growth factor-beta (TGF-beta) directed by an insulin promoter (Ins-TGF-beta mice) were used to assess the effect of local TGF-beta1 on allograft rejection and on autoimmune diabetes occurring as a cross-reaction to viral antigens. Pancreatic TGF-beta1 did not delay allograft rejection, nor did it inhibit autoimmune diabetes after lymphocytic choriomeningitis infection of double transgenic mice (LCMV/TGF-beta1 mice). These results suggest that local TGF-beta1 does not serve as an immunosuppressive agent for allograft rejection or virus-mediated autoimmune diabetes.

• Authors: M S Lee, S Sawyer, M Arnush, T Krahl, M von Herrath, M A Oldstone, N Sarvetnick
• Journal: Transplantation (Transplantation) Vol. 61 Issue 7 Pg. 1112-5 (Apr 15 1996) ISSN: 0041-1337 [Print] United States
• PMID: 8623195 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, P.H.S.)

Chemical References

• Transforming Growth Factor beta

Topics

• Animals
• Antigen Presentation (drug effects)
• Diabetes Mellitus, Type 1 (prevention & control)
• Graft Rejection (prevention & control)
• Lymphocytic Choriomeningitis (complications)
• Male
• Mice
• Mice, Inbred BALB C
• Mice, Inbred CBA
• Mice, Transgenic
• Pancreas Transplantation (immunology)
• Transforming Growth Factor beta (genetics, pharmacology)
• Transplantation, Homologous