Abstract | BACKGROUND AND PURPOSE: METHODS: Eighteen GM1 and 11 Control patients received GM1 300 mg or placebo, two doses intravenously, before nonemergency CS-CPB. Independent examiners administered structured neurological examinations and neuropsychological test batteries at Baseline and 1 day (Acute Postop; neurological only), 1 week (Early F/U), and > or = 6 months (Long-term F/U) postoperatively; using defined procedures they employed ordinal Clinical Change Scores (CCSs) to quantify neurological cerebral, neurological noncerebral, and neuropsychological performance changes. Several methods to analyze CCSs and neuropsychological test score changes were evaluated. RESULTS: The most sensitive indicators were the mean Acute Postop Neurologist's CCS-Cerebral (P < 10(-5)) and the mean Early F/U Neuropsychologist's CCS (P < .01), with statistically nonsignificant differences favoring GM1. No significant mean changes in Neurologist's CCS-Noncerebral or any Long-term F/U CCSs occurred. CCS distributions and neuropsychological test score mean changes showed similar temporal patterns, with less sensitivity to change. When, as usual in prior CS-CPB studies, impairment was defined by neuropsychological test score declines (increases ignored), results were spurious. CONCLUSIONS: The strokelike cerebral dysfunction (maximal acutely, with eventual recovery) that occurs after CS-CPB is useful to screen NPAs for clinical efficacy. CCSs based on detailed neurological examination and neuropsychological testing are sensitive measures; refinement of this approach should enhance the efficiency of the CS-CPB model. Further testing of GM1 is warranted.
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Authors | G Grieco, M d'Hollosy, A T Culliford, S Jonas |
Journal | Stroke
(Stroke)
Vol. 27
Issue 5
Pg. 858-74
(May 1996)
ISSN: 0039-2499 [Print] United States |
PMID | 8623106
(Publication Type: Clinical Trial, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Neuroprotective Agents
- Placebos
- G(M1) Ganglioside
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Brain Ischemia
(prevention & control)
- Cardiopulmonary Bypass
(adverse effects)
- Cognition
- Cognition Disorders
(prevention & control)
- Coronary Artery Bypass
- Coronary Disease
(surgery)
- Double-Blind Method
- Female
- Follow-Up Studies
- G(M1) Ganglioside
(therapeutic use)
- Heart Valve Prosthesis
- Humans
- Male
- Middle Aged
- Neuroprotective Agents
(therapeutic use)
- Neuropsychological Tests
- Placebos
- Postoperative Complications
(prevention & control)
- Probability
- Sensitivity and Specificity
- Time Factors
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