Treatment of vaginitis.

Abstract

OBJECTIVE:

The purpose of this study was to evaluate the efficacy of metronidazole 500 mg and miconazole nitrate 100 mg (Neo-Penotran, Embil Pharmacy Company, Istanbul, Turkey) in the treatment of vaginitis.

METHOD:

One hundred patients (mean age 26.5 years, range 18-50) with a clinical diagnosis of vaginitis entered this open, noncomparative study. Each patient inserted a Neo-Penotran pessary twice daily for 14 days. Assessments were carried out at the beginning of the study and 15 and 22 days after the start of therapy. Student's t-test was used for the statistical analysis.

RESULTS:

Out of 100 patients who were initially recruited to the study, 20 were subsequently excluded, leaving a total of 80 patients (80%) who completed the full course of treatment. Vaginitis was resolved in 75% of cases, it improved in 18% and was unchanged in 7%. The success rate for the treatment of trichomoniasis was 80%, 93.4% for bacterial vaginosis and 84.4% for candidal vaginitis.

CONCLUSION:

Neo-Penotran pessaries represent a novel and effective formulation for the treatment of common types of vaginitis and this pessary may also be of particular value in the treatment of resistant or recurrent vaginitis.

• Authors: S Kükner, T Ergin, N Ciçek, M Uğur, H Yeşilyurt, O Gökmen
• Journal: International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics (Int J Gynaecol Obstet) Vol. 52 Issue 1 Pg. 43-7 (Jan 1996) ISSN: 0020-7292 [Print] United States
• PMID: 8620988 (Publication Type: Clinical Trial, Journal Article)

Chemical References

• Antifungal Agents
• Antitrichomonal Agents
• Metronidazole
• Miconazole

Topics

• Adult
• Antifungal Agents (therapeutic use)
• Antitrichomonal Agents (therapeutic use)
• Candidiasis, Vulvovaginal (drug therapy)
• Female
• Humans
• Metronidazole (therapeutic use)
• Miconazole (therapeutic use)
• Middle Aged
• Treatment Outcome
• Trichomonas Vaginitis (drug therapy)
• Vaginosis, Bacterial (drug therapy)