Abstract | BACKGROUND: PURPOSE: RESULTS: PAF is an endogenous phospholipid involved in hypersensitivity and inflammatory reactions such as platelet and neutrophil aggregation, vasodilation, increased vascular permeability, and leukocyte adhesion, which have been associated with inflammatory processes. Cytokines are peptides that regulate and coordinate inflammatory and immunologic responses. Increased production of cytokines has been reported during Crohn's disease and ulcerative colitis and is correlated with disease activity. CONCLUSIONS: Because PAF and cytokines may have an important role in the pathogenesis of inflammatory bowel disease, their inhibition by specific antagonists, mediators, or other agents such as steroids may have a potential therapeutic benefit in treatment and management of these inflammatory diseases in the near future.
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Authors | A Nassif, W E Longo, J E Mazuski, A M Vernava, D L Kaminski |
Journal | Diseases of the colon and rectum
(Dis Colon Rectum)
Vol. 39
Issue 2
Pg. 217-23
(Feb 1996)
ISSN: 0012-3706 [Print] United States |
PMID | 8620791
(Publication Type: Journal Article, Review)
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Chemical References |
- Cytokines
- Platelet Activating Factor
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Topics |
- Animals
- Cytokines
(antagonists & inhibitors, physiology)
- Humans
- Inflammatory Bowel Diseases
(drug therapy, physiopathology)
- Platelet Activating Factor
(antagonists & inhibitors, physiology)
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