Short-term topical therapy of experimental tinea pedis in guinea pigs with lanoconazole, a new imidazole antimycotic agent.

Abstract

The therapeutic efficacy of short-term treatment with a 1% cream of lanoconazole, a new imidazole antimycotic agent, in comparison with that of a 1% cream of terbinafine was evaluated in the guinea pig model of tinea pedis. Each agent was topically applied once a day for 3 or 7 consecutive days, starting on day 10 postinfection, and a culture study was conducted on day 5 after the last treatment with each agent. The 1% cream of lanoconazole was as highly effective as the 1% cream of terbinafine in terms of eradicating the fungi from the infected feet.

• Authors: Y Niwano, T Tabuchi, K Kanai, H Hamaguchi, K Uchida, H Yamaguchi
• Journal: Antimicrobial agents and chemotherapy (Antimicrob Agents Chemother) Vol. 39 Issue 10 Pg. 2353-5 (Oct 1995) ISSN: 0066-4804 [Print] United States
• PMID: 8619597 (Publication Type: Journal Article)

Chemical References

• Antifungal Agents
• Heterocyclic Compounds
• Imidazoles
• latoconazole

Topics

• Administration, Topical
• Animals
• Antifungal Agents (therapeutic use)
• Guinea Pigs
• Heterocyclic Compounds (therapeutic use)
• Imidazoles (therapeutic use)
• Male
• Tinea Pedis (drug therapy, pathology)