Abstract | AIM: To study basal pepsinogen I levels in patients with duodenal ulcer and in subjects with normal endoscopy, depending on Helicobacter pylori status. METHODS: One-hundred and one patients with duodenal ulcer and 74 controls with normal endoscopy were studied. Mean age and gender distribution were: 46 vs 42 years, and 74% vs 43% males, respectively. At endoscopy biopsies from the gastric antrum and body were obtained for histologic (H&E) and microbiologic (Gram and culture) study. Basal levels of serum pepsinogen I were measured (RIA). RESULTS: Among the subjects with a normal endoscopy, those with H. pylori infection had higher pepsinogen I levels (m +/- SD) than non-infected patients (77 +/- 27 vs 62 +/- 28 ng/ml; p < 0.05). Basal levels in duodenal ulcer patients were 107 +/- 38 ng/ml, higher (p < 0.001) than in the group with normal endoscopy (both with and without H. pylori). In multivariate analysis pepsinogen I levels were correlated with H. pylori infection (regression coef.= 17; SE= 8.1), duodenal ulcer (regr. coef.= 22; SE= 5.8) and smoking habit (regr. coef.= 24; SE= 5.2). CONCLUSION: Basal pepsinogen I levels were significantly higher in duodenal ulcer patients than in H. pylori infected subjects with normal endoscopy. The lowest levels corresponded to non-infected patients. Therefore, an additional factor other than H. pylori infection is likely involved in the hyperpepsinogenemia classically reported in duodenal ulcer patients.
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Authors | J P Gisbert, D Boixeda, T Vila, L de Rafael, C Redondo, C Martín de Argila, C Arocena |
Journal | Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva
(Rev Esp Enferm Dig)
Vol. 88
Issue 1
Pg. 3-8
(Jan 1996)
ISSN: 1130-0108 [Print] Spain |
Vernacular Title | Niveles basales de pepsinógeno I sérico e infección por Helicobacter pylori en pacientes con úlcera duodenal y endoscopia normal. |
PMID | 8615998
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adult
- Aged
- Data Interpretation, Statistical
- Duodenal Ulcer
(blood, diagnosis)
- Endoscopy
- Female
- Gastritis
(blood, diagnosis)
- Helicobacter Infections
(blood, diagnosis)
- Helicobacter pylori
- Humans
- Male
- Middle Aged
- Pepsinogens
(blood)
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