[Basal levels of blood pepsinogen I and Helicobacter pylori infection in patients with duodenal ulcer and normal endoscopy].

Abstract

AIM:

To study basal pepsinogen I levels in patients with duodenal ulcer and in subjects with normal endoscopy, depending on Helicobacter pylori status.

METHODS:

One-hundred and one patients with duodenal ulcer and 74 controls with normal endoscopy were studied. Mean age and gender distribution were: 46 vs 42 years, and 74% vs 43% males, respectively. At endoscopy biopsies from the gastric antrum and body were obtained for histologic (H&E) and microbiologic (Gram and culture) study. Basal levels of serum pepsinogen I were measured (RIA).

RESULTS:

Among the subjects with a normal endoscopy, those with H. pylori infection had higher pepsinogen I levels (m +/- SD) than non-infected patients (77 +/- 27 vs 62 +/- 28 ng/ml; p < 0.05). Basal levels in duodenal ulcer patients were 107 +/- 38 ng/ml, higher (p < 0.001) than in the group with normal endoscopy (both with and without H. pylori). In multivariate analysis pepsinogen I levels were correlated with H. pylori infection (regression coef.= 17; SE= 8.1), duodenal ulcer (regr. coef.= 22; SE= 5.8) and smoking habit (regr. coef.= 24; SE= 5.2).

CONCLUSION:

Basal pepsinogen I levels were significantly higher in duodenal ulcer patients than in H. pylori infected subjects with normal endoscopy. The lowest levels corresponded to non-infected patients. Therefore, an additional factor other than H. pylori infection is likely involved in the hyperpepsinogenemia classically reported in duodenal ulcer patients.

• Authors: J P Gisbert, D Boixeda, T Vila, L de Rafael, C Redondo, C Martín de Argila, C Arocena
• Journal: Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva (Rev Esp Enferm Dig) Vol. 88 Issue 1 Pg. 3-8 (Jan 1996) ISSN: 1130-0108 [Print] Spain
• Vernacular Title: Niveles basales de pepsinógeno I sérico e infección por Helicobacter pylori en pacientes con úlcera duodenal y endoscopia normal.
• PMID: 8615998 (Publication Type: Comparative Study, Journal Article)

Chemical References

• Pepsinogens

Topics

• Adult
• Aged
• Data Interpretation, Statistical
• Duodenal Ulcer (blood, diagnosis)
• Endoscopy
• Female
• Gastritis (blood, diagnosis)
• Helicobacter Infections (blood, diagnosis)
• Helicobacter pylori
• Humans
• Male
• Middle Aged
• Pepsinogens (blood)