Re-evaluation of the "week-end effect" data: possible role of urinary copper and phosphorus in the pathogenesis of renal calculi.

Abstract

Early morning urinary concentrations of 10 elements which had demonstrated a "week-end effect" in a previous study, were subjected to a normalization procedure thereby allowing a re-assessment of their potential role in urolithiasis. After transformation of each concentration to a weighted proportion of the total concentration on each day, only Cu and P values were significantly different for kidney stone formers and healthy controls on all three days indicating that these elements may play a role in the pathogenesis of renal calculi. The results obtained in this study demonstrate that a more meaningful picture of the possible differences in the urinary concentrations of stone formers and normal controls might emerge if "proportional" rather than "raw" concentrations are compared.

• Authors: A L Rodgers, L J Barbour, B M Pougnet, C J Lombard, R L Ryall
• Journal: Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) (J Trace Elem Med Biol) Vol. 9 Issue 3 Pg. 150-5 (Oct 1995) ISSN: 0946-672X [Print] Germany
• PMID: 8605603 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Phosphorus
• Sulfur
• Copper
• Sodium
• Magnesium
• Zinc
• Potassium
• Bromine
• Calcium
• Strontium

Topics

• Bromine (urine)
• Calcium (urine)
• Copper (urine)
• Humans
• Kidney Calculi (etiology, physiopathology, urine)
• Magnesium (urine)
• Male
• Phosphorus (urine)
• Potassium (urine)
• Reference Values
• Sodium (urine)
• Spectrometry, X-Ray Emission
• Spectrophotometry, Atomic
• Statistics as Topic
• Strontium (urine)
• Sulfur (urine)
• Zinc (urine)