Increased plasma-soluble fibrin monomer levels in patients with disseminated intravascular coagulation.

Abstract

Plasma-soluble fibrin monomer (SFM) level in patients with disseminated intravascular coagulation (DIC) was significantly higher than the level in patients with pre-DIC or in non-DIC patients, and the level in patients with pre-DIC was significantly higher than that in non-DIC patients. There was no significant difference in plasma SFM levels among various diseases underlying DIC. Plasma SFM level in patients with good outcome was significantly decreased after treatment for DIC. The sensitivity of fibrin degradation products and platelet number was high for DIC, but not for pre-DIC. The sensitivity of thrombin-antithrombin III complex, plasmin-plasmin inhibitor complex, and SFM was high for both DIC and pre-DIC. The specificity of these markers was also high. Receiver operating characteristic analysis suggests that plasma SFM level could be the most useful marker for the diagnosis of both DIC and pre-DIC.

• Authors: H Wada, Y Wakita, T Nakase, M Shimura, K Hiyoyama, S Nagaya, H Deguchi, Y Mori, T Kaneko, K Deguchi, J Fujii, H Shiku
• Journal: American journal of hematology (Am J Hematol) Vol. 51 Issue 4 Pg. 255-60 (Apr 1996) ISSN: 0361-8609 [Print] United States
• PMID: 8602623 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Monoclonal
• Fibrin Fibrinogen Degradation Products
• fibrinmonomer
• Fibrin

Topics

• Amino Acid Sequence
• Animals
• Antibodies, Monoclonal (immunology)
• Blood Coagulation Tests
• Disseminated Intravascular Coagulation (blood, mortality)
• Enzyme-Linked Immunosorbent Assay
• Fibrin (immunology)
• Fibrin Fibrinogen Degradation Products (analysis)
• Humans
• Leukemia (blood)
• Molecular Sequence Data
• Neoplasms (blood)
• Platelet Count
• Prognosis
• Retrospective Studies
• Sensitivity and Specificity
• Sepsis (blood)