Abstract | BACKGROUND: PATIENTS AND METHODS: RESULTS: In both cases the characteristic chimeric rearrangement was demonstrated. Case no. 2 in addition to the t(15;17) showed an inversion of the long arm of a chromosome no. 5 and a del(7)(q22) in all abnormal mitoses studied. Despite these findings the patient obtained a complete morphological and cytogenetic remission of the leukemia following treatment with all-trans-retinoic acid. CONCLUSIONS:
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Authors | L Hoffmann, P Möller, J Pedersen-Bjergaard, A Waage, M Pedersen, F R Hirsch |
Journal | Annals of oncology : official journal of the European Society for Medical Oncology
(Ann Oncol)
Vol. 6
Issue 8
Pg. 781-8
(Oct 1995)
ISSN: 0923-7534 [Print] England |
PMID | 8589015
(Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Topoisomerase II Inhibitors
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Topics |
- Adult
- Antineoplastic Combined Chemotherapy Protocols
(adverse effects)
- Base Sequence
- Breast Neoplasms
(drug therapy)
- Female
- Humans
- Leukemia, Promyelocytic, Acute
(enzymology, etiology, genetics)
- Male
- Middle Aged
- Molecular Sequence Data
- Neoplasms, Second Primary
(enzymology, etiology, genetics)
- Seminoma
(drug therapy)
- Testicular Neoplasms
(drug therapy)
- Topoisomerase II Inhibitors
- Translocation, Genetic
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