Clinical evaluation of intravenous minocycline.

Abstract

24 patients with severe infections were treated with intravenous minocycline 100 mg every 12 hours. Average blood levels were within therapeutic ranges during the first 12 hours after the initial dose. Determination of efficacy of therapy in 23 of the patients who were evaluable showed that clinical and bacteriological results were satisfactory in 20 patients, unsatisfactory in 2, and questionable in 1. One patient developed a fatal secondary infection which may have been related to prior therapy with minocycline. No toxicities or side-effects were observed.

• Authors: J H Rogers, P A Barnwell, N G Waterman, F D Austin, M J Raff
• Journal: International journal of clinical pharmacology and biopharmacy (Int J Clin Pharmacol Biopharm) Vol. 15 Issue 4 Pg. 194-8 (Apr 1977) ISSN: 0340-0026 [Print] Germany
• PMID: 858651 (Publication Type: Journal Article)

Chemical References

• Tetracyclines
• Minocycline

Topics

• Adolescent
• Adult
• Aged
• Bacterial Infections (drug therapy)
• Cellulitis (drug therapy)
• Humans
• Injections, Intravenous
• Middle Aged
• Minocycline (therapeutic use)
• Respiratory Tract Infections (drug therapy)
• Tetracyclines (therapeutic use)
• Urinary Tract Infections (drug therapy)