Abstract | BACKGROUND/AIMS: METHODS: RESULTS: A marked difference in human leucocyte antigen frequency was limited to DQ6, which was found in 66.7% of cystic fibrosis patients with liver disease compared to 32.9% of patients with no liver disease (Pc < 0.03) and 28.8% of controls (Pc < 0.006). An increased frequency of the two antigens in strong linkage disequilibrium with DQ6 was also observed within this patient group, namely DR15 and B7. When the patients were stratified for the presence of portal hypertension, these observations were confirmed, but the human leucocyte antigen associations were significant only for male patients and there was no association with the age of onset of liver disease. CONCLUSIONS: These data suggest that the haplotype B7-DR15-DQ6 may carry an increased risk of development of liver disease in male cystic fibrosis patients.
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Authors | A Duthie, D G Doherty, P T Donaldson, R Scott-Jupp, M S Tanner, A L Eddleston, A P Mowat |
Journal | Journal of hepatology
(J Hepatol)
Vol. 23
Issue 5
Pg. 532-7
(Nov 1995)
ISSN: 0168-8278 [Print] Netherlands |
PMID | 8583140
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Complement C4
- Steroid 21-Hydroxylase
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Topics |
- Adolescent
- Adult
- Case-Control Studies
- Child
- Child, Preschool
- Chronic Disease
- Complement C4
(genetics)
- Cystic Fibrosis
(enzymology, genetics)
- Disease Progression
- Female
- Genes, MHC Class I
- Genes, MHC Class II
- Humans
- Infant
- Liver Diseases
(enzymology, genetics)
- Male
- Phenotype
- Polymorphism, Restriction Fragment Length
- Steroid 21-Hydroxylase
(genetics)
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