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Evolution of severe aplastic anemia to myelodysplasia with monosomy 7 following granulocyte colony-stimulating factor, erythropoietin and high-dose methylprednisolone combination therapy.

Abstract
A 19-year-old man was diagnosed as having severe aplastic anemia and received high-dose methylprednisolone treatment without hematological response. A second course of high-dose mPSL treatment together with granulocyte colony-stimulating factor (G-CSF) plus erythropoietin (EPO) was then started and resulted in trilineage blood cell response. Ten months after the combination therapy thrombocytopenia developed and cytogenetic analysis showed 45,XX,-7, indicating an evolution to myelodysplastic syndrome (MDS) associated with monosomy 7.G-CSF and EPO treatment together with immunosuppression may be an effective therapy in SAA patients, but such a therapy may increase the risk of evolution to MDS.
AuthorsA Ohsaka, Y Sugahara, Y Imai, M Kikuchi
JournalInternal medicine (Tokyo, Japan) (Intern Med) Vol. 34 Issue 9 Pg. 892-5 (Sep 1995) ISSN: 0918-2918 [Print] Japan
PMID8580564 (Publication Type: Case Reports, Journal Article)
Chemical References
  • Glucocorticoids
  • Erythropoietin
  • Granulocyte Colony-Stimulating Factor
  • Methylprednisolone
Topics
  • Adult
  • Anemia, Aplastic (complications, drug therapy)
  • Chromosomes, Human, Pair 7 (genetics)
  • Drug Therapy, Combination
  • Erythropoietin (adverse effects)
  • Glucocorticoids (adverse effects)
  • Granulocyte Colony-Stimulating Factor (adverse effects)
  • Humans
  • Male
  • Methylprednisolone (adverse effects)
  • Monosomy (genetics)
  • Myelodysplastic Syndromes (chemically induced, genetics)

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