Abstract | BACKGROUND: METHODS: Aliquots of H. pylori culture were transferred to the wells containing different concentrations of antibiotics either alone or in the presence of various doses of sucralfate and omeprazole and incubated for 3 days for MIC evaluation. RESULTS: The assays in the absence of sucralfate and omeprazole gave MIC value 0.10 mg/l for erythromycin, 0.12 mg/l for amoxycillin, 0.15 mg/l for tetracycline, and 14 mg/l for metronidazole. Inclusion of sucralfate evoked a 28% enhancement in the MIC of metronidazole, 2.5-fold in tetracycline, 8-fold in erythromycin, and 2-fold in amoxycillin. In the presence of omeprazole, the MIC of erythromycin improved 4-fold, tetracycline 1.6-fold, and amoxycillin, 2-fold. CONCLUSIONS:
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Authors | B L Slomiany, J Piotrowski, J Majka, A Slomiany |
Journal | Scandinavian journal of gastroenterology. Supplement
(Scand J Gastroenterol Suppl)
Vol. 210
Pg. 82-4
( 1995)
ISSN: 0085-5928 [Print] England |
PMID | 8578215
(Publication Type: Journal Article)
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Chemical References |
- Anti-Bacterial Agents
- Anti-Ulcer Agents
- Penicillins
- Metronidazole
- Sucralfate
- Erythromycin
- Amoxicillin
- Tetracycline
- Omeprazole
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Topics |
- Amoxicillin
(pharmacology)
- Anti-Bacterial Agents
(pharmacology)
- Anti-Ulcer Agents
(pharmacology)
- Drug Interactions
- Erythromycin
(pharmacology)
- Helicobacter pylori
(drug effects)
- Humans
- Metronidazole
(pharmacology)
- Microbial Sensitivity Tests
- Omeprazole
(pharmacology)
- Penicillins
(pharmacology)
- Sucralfate
(pharmacology)
- Tetracycline
(pharmacology)
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