Abstract |
The rationale for and effectiveness of extended dosage intervals for aminoglycosides are reviewed. Aminoglycoside antibiotics have a prolonged postantibiotic effect against a variety of common Gram-negative and Gram-positive organisms: higher serum aminoglycoside levels are associated with a longer postantibiotic effect and increased bactericidal activity. Moreover once daily aminoglycoside administration may reduce the potential for adaptive postexposure resistance by allowing less contact time between bacteria and antibiotic. A longer dosage interval may decrease the risk of nephro- and ototoxicity. At least 33 published clinical trials suggest that once-daily administration of aminoglycosides and conventional regimens involving shorter dosage intervals are equally effective in patients with normal renal function and Gram-negative infections: besides, once-daily administration may reduce the frequency of aminoglycoside toxicity or delay it.
|
Authors | P Periti |
Journal | Journal of chemotherapy (Florence, Italy)
(J Chemother)
Vol. 7
Issue 4
Pg. 311-37
(Aug 1995)
ISSN: 1120-009X [Print] England |
PMID | 8568543
(Publication Type: Comparative Study, Journal Article, Review)
|
Chemical References |
- Aminoglycosides
- Anti-Bacterial Agents
- Lactams
|
Topics |
- Aminoglycosides
- Animals
- Anti-Bacterial Agents
(administration & dosage, adverse effects, blood, pharmacokinetics, pharmacology, therapeutic use)
- Clinical Trials as Topic
- Colony Count, Microbial
- Drug Administration Schedule
- Drug Evaluation
- Drug Resistance, Microbial
- Drug Therapy, Combination
(administration & dosage, adverse effects, pharmacology)
- Humans
- In Vitro Techniques
- Lactams
- Microbial Sensitivity Tests
- Structure-Activity Relationship
|